Improving Muscle Regeneration in Muscular Dystrophy

Using AAV vectors expressing the β 2 -adrenoceptor or associated Gα proteins to modulate skeletal muscle mass and muscle fibre size

A Hagg, TD Colgan, RE Thomson, H Qian, GS Lynch, P Gregorevic

2016-03-14

Anabolic β 2 -adrenoceptor (β 2 -AR) agonists have been proposed as therapeutics for treating muscle wasting but concerns regardin..

Functional β-adrenoceptors are important for early muscle regeneration in mice through effects on myoblast proliferation and differentiation

JE Church, J Trieu, R Sheorey, AYM Chee, T Naim, DM Baum, JG Ryall, P Gregorevic, GS Lynch

2014-07-07

Muscles can be injured in different ways and the trauma and subsequent loss of function and physical capacity can impact significa..

Emerging drugs for treating skeletal muscle injury and promoting muscle repair

SM Gehrig, GS Lynch

2011-03-01

Introduction: Musculoskeletal injuries represent a major global public health problem and muscle injury contributes significantly ..

Role of β-adrenergic signalling in skeletal muscle wasting: Implications for sarcopenia

JG Ryall, GS Lynch

2011-01-01

While the importance of β-adrenergic signalling in the heart has been well documented for more than half a century and continues t..

Cellular mechanisms underlying temporal changes in skeletal muscle protein synthesis and breakdown during chronic β-adrenoceptor stimulation in mice

R Koopman, SM Gehrig, B Léger, J Trieu, S Walrand, KT Murphy, GS Lynch

2010-12-01

Chronic stimulation of β-adrenoceptors with β-adrenoceptor agonists (β-agonists) can induce substantial skeletal muscle hypertroph..

Novel role for β-adrenergic signalling in skeletal muscle growth, development and regeneration: Proceedings of the Australian physiological society symposium: Signals mediating exercise-induced skeletal muscle remodelling

JG Ryall, JE Church, GS Lynch

2010-03-01

In adult mammals, skeletal muscle mass is maintained through a precise balance of protein synthesis and protein degradation, where..

Update on emerging drugs for cancer cachexia

KT Murphy, GS Lynch

2009-12-01

Cancer cachexia is a complex syndrome that describes the progressive muscle wasting and weakness in many cancer patients. Muscle w..

The role of β-adrenoceptor signaling in skeletal muscle: Therapeutic implications for muscle wasting disorders

R Koopman, JG Ryall, JE Church, GS Lynch

2009-11-01

PURPOSE OF REVIEW: The β-adrenergic signaling pathway represents a novel therapeutic target for skeletal muscle wasting disorders ..

The potential and the pitfalls of β-adrenoceptor agonists for the management of skeletal muscle wasting

JG Ryall, GS Lynch

2008-12-01

The β-adrenergic signaling pathway represents a novel therapeutic target for skeletal muscle wasting and weakness due to its role ..

Update on emerging drugs for sarcopenia - Age-related muscle wasting

GS Lynch

2008-12-01

Sarcopenia - the progressive loss of muscle mass with advancing age is characterised by a deterioration of muscle quantity and qua..

Cellular and molecular mechanisms underlying age-related skeletal muscle wasting and weakness

JG Ryall, JD Schertzer, GS Lynch

2008-08-01

Some of the most serious consequences of ageing are its effects on skeletal muscle. The term 'sarcopenia' describes the slow but p..

Anabolic agents for improving muscle regeneration and function after injury

GS Lynch, JD Schertzer, JG Ryall

2008-07-01

1. In the present review, we describe how muscles can be injured by external factors, internal factors or during the performance o..